Your payroll tax and non-tax liabilities accrue each time you run payroll or make a liability adjustment. If you've set up scheduled payments for your payroll taxes, the payments appear along with a Send By date in the Pay Scheduled Liabilities section in the Payroll Center.
Many employers wait until the Send By date to make scheduled tax payments. You can, however, pay your payroll liabilities at any time, regardless of the Send By date. For example, you can pay your payroll liabilities after each payroll run. To do so, simply return to the Payroll Center and pay your scheduled tax payments.
If you haven't set up scheduled payments yet, you can still pay your payroll taxes and other liabilities now by creating a custom (unscheduled) payment.
About scheduled payments
Payroll Tax Compliance